•Deficiencies of both are common in NDNS
65+
•
•Supplement use is associated with better
folate status but
only slightly better vit B12 status
Dangour A et al J. Nutr.
2008 138;1121-1128
•
•US NHANES III: those with a serum B12 <148 pmol/l (~35% of UK elderly) increasing serum
folate was associated
with increased HCys and MMA levels
Selhub J et
al Am J Clin Nutr 2009;89(2):702S-706S
•
•European EPIC no overall association of
prostate cancer risk
and the status of these nutrients
However
in those with a high vitamin B12 level there was an increased risk of more advanced
disease.
Johansson M
et al Cancer Epidemiol Biomarkers Prev 2008;17(2):279-85
See also Hultdin J et al
Int J Cancer 2004;113:819-24