Iowa Women’s Health Study: Supplements &
Mortality
Mursu J et al. Arch Intern Med 2011;171(18):1625-33
Mursu J et al. Arch Intern Med 2011;171(18):1625-33
•38,772 women mean 61.6 yr in 1986; 40.2% died
by end 2008
•Supplement use in 1986, 1997 and 2004 was
associated with an increased
mortality, which may have been due to pre-existing illness
•Particular concerns about use of
copper-containing products
+
3.0%
1.01
to 1.15
1.08
Zinc
+
18%
1.20
to 1.7
1.45
Copper
+
3.6%
1.01
to 1.15
1.08
Magnesium
+
3.9%
1.03
to 1.17
1.1
Iron
+
5.9%
1.00
to 1.32
1.15
Folic
acid
+
4.1%
1.01
to 1.21
1.1
Vit
B6
+
2.4%
1.02
to 1.1
1.06
Multivitamins
-
3.8%
0.8
to 0.94
0.91
Calcium
Absolute Risk
Confidence Intervals
Hazard Ratio
Nutrient(s) Provided by Supplement