•83 patients with three genotypes for MTHFR enzyme (folate metabolism)
•Increased cardiovascular risk homozygous for 677C->T polymorphism
•31 with TT genotype had higher systolic BP, unresponsive to drug treatment
•Given riboflavin 1.6 mg/day 2004 & 2008
•Fall in BP
Sys -9.2 +
12.8 mmHg
Dias -6.0 + 9.9 mmH