•Regularly used to treat/prevent osteoporotic
fractures
•
•Used standardly in conjunction with all bisphosphonates
•
•Large placebo-controlled trial of daily
supplements of:
calcium 1000mg
vitamin D3 400 IU (10ug)
36,282
postmenopausal women aged 50-79 years
•
•Slight improvement in hip bone density
•
•No reduction in fracture risk
•
•Increased risk of kidney stone formation -
17%
•
•NEJM 2006;354:669-682