•Deficiencies of both are common in UK (NDNS 65+)
•
•Supplement use is associated with better folate status but only slightly better vit B12 status (Dangour
2008)
•
•NHANES III in the US: those with a serum B12 <148 pmol/l (~35% of UK elderly) increasing serum folate was associated with increased HCys and MMA
levels
Selhub J et al Am J Clin
Nutr 2009;89(2):702S-706S
•
•EPIC no overall association of prostate cancer risk and the status of these nutrients
However in those
with a high vitamin B12 level there was an increased risk of more advanced disease.
Johansson M et al Cancer
Epidemiol Biomarkers Prev 2008;17(2):279-85
See also Hultdin J et al Int J Cancer
2004;113:819-24
•
•Ca Prostate patients are more likely to die from renal
failure