•Abnormal LFTs may occur in 10% - 30% of UK adults
•
•
•Common causes:
- Alcohol excess
- Obesity - NAFLD
- Hepatitis B and
C
- Drug-induced
- Auto-immune liver disease
•
•
•Elevated Alkaline Phosphatase -
cholestatic liver disease
- increased
mortality
•
•
•Elevated Gamma GT
- usually alcohol
excess
•
•
•
•Abnormal LFTS
- potential accumulation Mn, Cu -
altered vitamin A status
- reduced 25(OH) vit.D