Clinical
Picture of Chronic Retinol Excess
Reason or
Clinical Picture
High from
liver, fortified foods, supplements
?Increased
in fast beta-carotene converters
Reduced in
renal impairment
Reduced
storage in liver disease and alcohol XS. Increased RBP4 if obese, T2D or ?Na valproate. More
susceptible to osteoporosis if vit D deficient
Increase in
serum, liver and CSF levels
Headache,
fatigue if hypercalcaemia
Raised
CSF pressure, dry skin, hair loss, abnormal liver function tests, bone changes – loss of height
Osteop. #,
pregnancy deformity, ?cancer growth